Well…

Ha yes, the Last Ordovician Mas Extinction.

You seem to think that a double blind study is to measure the effect of a medication against “no medication”, but it is, in fact, to measure effect against placebo. Double blind is specifically designed to remove experimentator effect in a full consent framework. In fact, the study that are not done with consent, generally in a single blind (the experimentated) are always frowned upon by the community for good reasons.